About Michael Thomas Wolfinger

My research covers different aspects of algorithmic RNA bioinformatics, including:

  • Prediction of RNA secondary structures
  • RNA folding dynamics and (re-)folding pathways
  • In silico design of riboswitches for synthetic RNA biology
  • RNA regulation in bacteria, archaea, and viruses
  • Comparative genomics and virus evolution
  • Discrete energy landscapes of biopolymers
  • Equilibrium and non-equilibrium properties of complex disordered systems
  • Efficient sampling strategies

I am particularly interested in viruses, whose relatively small yet diverse genomes provide a rich portfolio of characteristic traits that can be studied by theoretical approaches. In this line, I am developing custom virus bioinformatics tools such as RNAaliSplit or plfoldz. Collaborations with virologists, RNA biologists, and clinical scientists resulted in the development of ViennaNGS, a collection of applications for next-generation sequencing (NGS) analysis and comparative RNA genomics.